Met Music Director Yannick Nézet-Séguin takes the podium on May 17 to conduct Strauss’s one-act tragedy. Leading the company’s first new production of the work in 20 years, Claus Guth, one of Europe’s leading opera directors, gives the biblical story a psychologically perceptive Victorian-era setting. South African soprano Elza van den Heever leads the cast as the abused and unhinged antiheroine, with Swedish baritone Peter Mattei as the imprisoned prophet Jochanaan; German tenor Gerhard Siegel as Salome’s lecherous stepfather, King Herod; American mezzo-soprano Michelle DeYoung as his wife, Herodias; and Polish tenor Piotr Buszewski as Narraboth.